Custom Peptides
Cayman Chemical 17-OctadecynoIc AcId 10mg
A fatty acid alkyne; a suicide inhibitor of leukotriene B4 20-hydroxylase and renal CYP450 ω-hydroxylase; completely inhibits the bradykinin-dependent transport of sodium chloride in rat TALH cells; has been used as a click chemistry probe for labeling palmitoylation substrates in vitro; has been used to study the formation of lipid droplets in live THP-1 macrophages and C. elegans
Cayman Chemical 12-methyl TrIdecnoIc AcId 10mg
A methylated fatty acid; has been found in bovine milk; topical ocular application decreases angiogenesis and corneal opacity in mouse models of alkali- or P. aeruginosa-induced eye injury at 200 µM
Cayman Chemical TechtochrysIn 10mg
A flavonoid with diverse biological activities; induces adipogenesis and glucose uptake in 3T3-L1 adipocytes at 12.5, 25, and 50 UG/ml; active against S. aureus, L. monocytogenes, B. subtilis, S. enterica, E. coli, V. cholera, K. pneumonia, S. dysenteriae, and P. aeruginosa (MICs = 24-64 UG/ml); scavenges peroxyl radicals in a cell-free assay at 1 and 10 µM
Cayman Chemical Gastroda elta Parshn B 10mg
A phenolic glycoside with anti-asthmatic activity; decreases specific airway resistance and leukocyte infiltration in BALF in a guinea pig model of allergen-induced asthma stimulated by ovalbumin inhalation at 50 mg/kg
Cayman Chemical 3-epI UrsolIc AcId 10mg
A pentacyclic triterpenoid; inhibits glycogen phosphorylase and cathepsin L but not cathepsin B (IC50s = 19, 6.5, and >250 µM, respectively); inhibits entry of bovine parainfluenza virus 3 into MDBK cells at 20-50 µM; inhibits the proliferation of MCF-7 cells (IC50 = 18.6 UG/ml)
Cayman Chemical 3-AmInocatechol 10mg
A synthetic intermediate; has been used in the synthesis of vicinal diols
Cayman Chemical DeferasIrox 10mg
An orally bioavailable iron chelator with anticancer activity; selective for (Fe(III) over Cu(II), Zn(II), Mg(II), and Ca(II) but does bind to Al(III); decreases iron levels in iron-loaded rat heart cells in vitro by 45.8 and 55.6% compared to control levels at 160 and 320 µM; decreases radiolabeled liver iron levels from 41 to 21.7% and blood iron levels from 8.2 to 3.4% in hypertransfused rats at 200 mg/kg; inhibits proliferation of SAS human oral squamous carcinoma cells (EC50 = 21 µM); act synergistically with gemcitabine in vitro to inhibit proliferation and in vivo to reduce tumor growth at 200 mg/kg in a BxPC-3 mouse xenograft model
Cayman Chemical Lacto-N-tetraose 10mg
An oligosaccharide; promotes the growth of the bacterium B. longum and B. breve; levels are increased in breast milk from mothers of rotavirus-positive neonates with gastrointestinal symptoms and are positively correlated with levels of Enterobacter and Klebsiella in maternal milk and infant stool
Cayman Chemical FluorofenIdon 10mg
An antifibrotic agent; inhibits angiotensin II-induced increases in TGF-β1 secretion and ROS production, as well as TGF-β1-induced production of collagen I, in NRK-52E cells at 8 mM; decreases disease severity and the renal levels of collagen I, collagen III, and CTGF in a rat model of obstructive nephropathy induced by unilateral ureteral obstruction at 500 mg/kg; increases survival in a mouse model of LPS-induced endotoxemia at 200 mg/kg
Cayman Chemical PhenIramInmaleate 10mg
An analytical reference standard categorized as an antihistamine; has antidepressant-like activity in rats; associated with fatal and non-fatal overdoses; intended for research and forensic applications
Cayman Chemical 8Methoxymethyl3Isobutyl1 10mg
A PDE1 inhibitor (IC50 = 5 µM); selective for PDE1 over PDE2, PDE3, and PDE4 but also inhibits PDE5 (IC50s = 37, >400, >400, and 2 µM, respectively); enhances forskolin-induced increases in intracellular calcium levels in isolated rat olfactory receptor neurons at 30 µM; induces relaxation of isolated human saphenous vein segments in the absence of endothelium (EC50 = 31 µM); enhances iloprost-induced decreases in pulmonary artery pressure and vascular resistance in a rabbit model of U-46619-induced pulmonary hypertension at 200 UG/kg
Cayman Chemical S-LInoleyl-2-Hydroxy-1 10mg
A homolog of LOEA, characterized by the addition of an (S)-β-methyl group at the terminal ethanolamine carbon
Cayman Chemical ErIodIctyol 7-O-glucosIde 10mg
A flavanone glucoside; scavenges hydroxyl and superoxide anion radicals in cell-free assays (IC50s = 0.28 and 0.3 mM, respectively); activates Nrf2 in a reporter assay; protects against cisplatin-induced cytotoxicity in HRMCs, but not A549 or MDA-MB-231 cells, at 80 µM; attenuates neurological deficits and reduces infarct volume in a rat model of MCAO-induced cerebral ischemia at 30 mg/kg
Cayman Chemical DocosahexaenoylLcarnItIn 10mg
A long-chain acylcarnitine; decreased venous cord plasma levels are associated with babies born small for gestational age